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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Adv Protein Chem Struct Biol. 2017 Oct 6;111:1–59. doi: 10.1016/bs.apcsb.2017.08.003

Fig. 8.

Fig. 8

Example of fragment-based approach. Two molecules with IC50 values of 100 and 330μM, respectively, were linked to obtain a high-affinity ligand that has an IC50 value of 37nM. Adapted from Erlanson, D. A. (2006). Fragment-based lead discovery:A chemical update. Current Opinion in Biotechnology, 17(6), 643–652. https://doi.org/10.1016/j.copbio.2006.10.007. Copyright (2006) Elsevier.