Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Adv Protein Chem Struct Biol. 2017 Oct 6;111:1–59. doi: 10.1016/bs.apcsb.2017.08.003

Fig. 9.

Fig. 9

Scheme of the simultaneous binding of bivalent ligands with linkers of appropriate length to two receptors in a GPCR dimer. The agonist/antagonist moieties of the bivalent ligand are selective for their respective receptors (orange for GPCR-I; green for GPCR-II) and are linked by a spacer. (A) Binding to two equal GPCRs forming a homo-dimer. (B) Binding to two different GPCRs forming a heterodimer. Reproduced with permission from Franco, R., Martinez-Pinilla, E., Lanciego, J. L., & Navarro, G. (2016). Basic pharmacological and structural evidence for class A g-protein-coupled receptor heteromerization. Frontiers in Pharmacology, 7, 76. https://doi.org/10.3389/fphar.2016.00076. Copyright (2016).