Table 3:
Rates of Herpes Zoster for Each Year by HIV serostatus and then by CD4 T-cell Count Strata and Viral Suppression in PLWH
| Year | Uninfected Rate/1000 (95% CI) | PLWH Rate/1000 (95% CI) | Rate/1000 (95% CI) by CD4 T-Cell Count (cells/μL) | Rate/1000 (95% CI) by HIV-1 RNA (copies/mL) | ||||
|---|---|---|---|---|---|---|---|---|
| ≤200 | 201–350 | 351–500 | >500 | Suppressed | Unsuppressed | |||
| 2002 | 2.3 (2.0, 2.7) | 17.6 (15.9, 19.2) | 38.0 (31.1, 44.8) | 21.7 (16.4, 26.9) | 20.2 (15.0, 25.5) | 14.9 (11.5, 18.3) | 16.4 (13.4, 19.4) | 29.7 (25.6, 33.8) |
| 2003 | 2.4 (2.0, 2.7) | 17.4 (15.7, 19.0) | 31.0 (24.5, 37.1) | 27.7 (21.8, 33.6) | 18.7 (13.9, 23.5) | 14.1 (10.9, 17.3) | 14.0 (11.3, 16.6) | 29.1 (25.1, 33.1) |
| 2004 | 2.7 (2.3, 3.1) | 17.0 (15.3, 18.6) | 33.1 (26.5, 39.6) | 22.3 (17.2, 27.3) | 14.7 (10.5, 19.0) | 13.5 (10.4, 16.4) | 13.9 (11.3, 16.5) | 26.5 (22.7, 30.3) |
| 2005 | 2.6 (2.2, 3.0) | 16.6 (15.0, 18.2) | 30.6 (24.2, 37.1) | 25.7 (20.3, 31.1) | 19.3 (14.6, 24.0) | 13.4 (10.5, 16.4) | 13.8 (11.3, 16.2) | 30.3 (26.1, 34.5) |
| 2006 | 2.6 (2.2, 2.9) | 16.6 (15.0, 18.2) | 29.7 (23.1, 36.3) | 24.4 (19.1, 29.7) | 17.7 (13.3, 22.0) | 14.7 (11.7, 17.8) | 13.2 (10.9, 15.5) | 31.1 (26.7, 35.6) |
| 2007 | 2.9 (2.5, 3.3) | 15.6 (14.0, 17.1) | 33.7 (26.4, 41.0) | 20.8 (15.9, 25.8) | 15.7 (11.6, 19.8) | 10.5 (8.0, 13.0) | 11.5 (9.4, 13.6) | 28.2 (23.7, 32.7) |
| 2008 | 3.6 (3.2, 4.1) | 15.7 (14.1, 17.2) | 31.8 (24.7, 38.9) | 15.3 (11.1, 19.6) | 19.6 (15.1, 24.1) | 13.3 (10.6, 16.1) | 13.9 (11.7, 16.1) | 28.6 (23.8, 33.3) |
| 2009 | 3.9 3.4, 4.3) | 14.4 (12.9, 15.9) | 34.6 (26.7, 42.4) | 18.9 (14.2, 23.6) | 14.7 (10.8, 18.6) | 9.5 (7.3, 11.6) | 10.7 (8.8, 12.5) | 31.0 (25.7, 36.3) |
| 2010 | 3.4 (3.0, 3.9) | 13.4 (11.9, 14.8) | 20.6 (14.2, 27.0) | 22.0 (16.9, 27.1) | 15.5 (11.6, 19.5) | 11.6 (9.3, 14.0) | 11.5 (9.7, 13.3) | 29.5 (24.0, 34.9) |
| 2011 | 3.6 (3.1, 4.0) | 13.3 (11.9, 14.8) | 31.6 (23.7, 39.6) | 17.5 (12.8, 22.2) | 12.1 (8.7, 15.6) | 11.5 (9.3, 13.7) | 11.6 (9.9, 13.4) | 29.1 (23.4, 34.8) |
| 2012 | 4.1 (3.6, 4.5) | 12.4 (11.0, 13.8) | 23.0 (16.0, 29.9) | 14.6 (10.2, 18.9) | 12.8 (9.3, 16.4) | 10.2 (8.2, 12.2) | 9.7 (8.1, 11.2) | 28.3 (22.4, 34.1) |
| 2013 | 4.7 (4.2, 5.2) | 10.0 (8.7, 11.2) | 19.8 (13.1, 26.5) | 12.2 (8.2, 16.2) | 12.8 (9.2, 16.4) | 7.0 (5.4, 8.6) | 9.0 (7.5, 10.4) | 16.8 (12.1, 21.5) |
| 2014 | 4.6 (4.0, 5.1) | 9.3 (8.0, 10.5) | 28.2 (19.7, 36.7) | 10.6 (6.7, 14.5) | 10.0 (6.8, 13.2) | 6.5 (5.0, 8.1) | 7.1 (5.8, 8.4) | 24.2 (18.2, 30.3) |
| 2015 | 4.1 (3.6, 4.6) | 8.1 (6.9, 9.2) | 18.0 (10.8, 25.1) | 14.4 (9.8, 19.0) | 7.5 (4.6, 10.3) | 6.8 (5.3, 8.3) | 7.1 (5.8, 8.3) | 21.8 (15.5, 28.1) |
PLWH, people living with HIV. Suppressed defined as a HIV-1 RNA ≤400 copies/mL and unsuppressed as a HIV-1 RNA >400 copies/mL. CI, confidence interval.