Table 2.
Rates of new damage, in subgroups defined by past levels of disease activity
| Percentage of Prior Months in: | Number of person-years observed | Number of damage events. | Rate of events per 10 person years | Rate Ratios (95% Confidence Intervals) | P-values |
|---|---|---|---|---|---|
| LLDAS | |||||
| None | 638 | 117 | 1.83 | 1.0 (Ref) | |
| Not none, but < 25% | 880 | 134 | 1.52 | 0.80 (0.61, 1.06) | 0.12 |
| 25% to 50% | 1057 | 129 | 1.22 | 0.63 (0.48, 0.84) | 0.0012 |
| 50% to 75% | 1513 | 133 | 0.88 | 0.47 (0.36, 0.62) | <0.0001 |
| 75%+ | 1095 | 82 | 0.75 | 0.39 (0.29, 0.53) | <0.0001 |
| Clinical Remission On Treatment1 | |||||
| None | 1374 | 250 | 1.82 | 1.0 (Ref) | |
| Not none, but < 25% | 1681 | 170 | 1.01 | 0.54 (0.44, 0.67) | <0.0001 |
| 25% to 50% | 1195 | 103 | 0.86 | 0.47 (0.36, 0.60) | <0.0001 |
| 50% to 75% | 700 | 54 | 0.77 | 0.43 (0.30, 0.60) | <0.0001 |
| 75%+ | 232 | 18 | 0.77 | 0.45 (0.27, 0.75) | 0.0019 |
| Clinical Remission No Treatment2 | |||||
| None | 2981 | 406 | 1.36 | 1.0 (Ref) | |
| Not none, but < 25% | 1197 | 102 | 0.85 | 0.60 (0.48, 0.75) | <0.0001 |
| 25% to 50% | 548 | 50 | 0.91 | 0.66 (0.46, 0.94) | 0.023 |
| 50% to 75% | 320 | 27 | 0.84 | 0.63 (0.42, 0.97) | 0.035 |
| 75%+ | 137 | 10 | 0.73 | 0.58 (0.30, 1.15) | 0.12 |
1
Requires Prednisone dose ≤ 5 mg/day, but allows for maintenance immunosuppressants and hydroxychloroquine.
2
Requires no use of prednisone or immunosuppressants, but allows for use of hydroxychloroquine