Table 3.
Numbers of specific types of damage events (rate per 10 person-years) in groups classified by prior LLDAS experience.
| Damage Type | Percentage of Prior visits in LLDAS | P-value for trend2 | ||||
|---|---|---|---|---|---|---|
| None (638 PY1) | <25% (880 PY1) | 25–50% (1057 PY1) | 50–75% (1513 PY1) | 75%+ (1095 PY1) | ||
| Arthritis (deforming or erosive) | 9 (0.15) | 6 (0.08) | 1 (0.01) | 6 (0.04) | 1 (0.01) | 0.0010 |
| Avascular Necrosis | 12 (0.23) | 14 (0.20) | 4 (0.05) | 7 (0.05) | 1 (0.01) | <0.0001 |
| Cataract | 12 (0.23) | 16 (0.23) | 11 (0.13) | 27 (0.21) | 16 (0.17) | 0.38 |
| Cognitive Impairment | 1 (0.02) | 4 (0.05) | 7 (0.07) | 3 (0.02) | 7 (0.07) | 0.71 |
| Cardiomyopathy | 4 (0.07) | 4 (0.05) | 3 (0.03) | 4 (0.03) | 1 (0.01) | 0.053 |
| Cranial or Peripheral Neuropathy | 3 (0.05) | 7 (0.09) | 9 (0.10) | 8 (0.06) | 3 (0.03) | 0.26 |
| Cerebrovascular Accident | 5 (0.09) | 5 (0.06) | 4 (0.04) | 4 (0.03) | 6 (0.06) | 0.34 |
| Diabetes mellitus | 3 (0.05) | 6 (0.07) | 3 (0.03) | 3 (0.02) | 1 (0.01) | 0.020 |
| End Stage Renal Disease | 11 (0.18) | 3 (0.04) | 3 (0.03) | 1 (0.01) | 1 (0.01) | 0.0001 |
| Glomerular Filtration Rate <50% | 7 (0.12) | 1 (0.01) | 0 (0.00) | 1 (0.01) | 0 (0.00) | 0.0046 |
| Infarction or resection of bowel below duodenum | 4 (0.07) | 8 (0.11) | 10 (0.11) | 3 (0.02) | 6 (0.06) | 0.076 |
| Malignancy | 6 (0.10) | 9 (0.11) | 11 (0.11) | 11 (0.08) | 8 (0.08) | 0.66 |
| Myocardial Infarction | 7 (0.11) | 3 (0.04) | 7 (0.07( | 3 (0.02) | 2 (0.02) | 0.0077 |
| Osteomyelitis | 4 (0.06) | 1 (0.01) | 1 (0.01) | 0 (0.00) | 1 (0.01) | 0.037 |
| Osteoporosis with fracture or vertebral collapse | 18 (0.31) | 18 (0.24) | 20 (0.22) | 22 (0.16) | 14 (0.14) | 0.0051 |
| Pleural Fibrosis | 4 (0.06) | 4 (0.05) | 5 (0.05) | 5 (0.03) | 1 (0.01) | 0.11 |
| Premature gonadal failure | 4 (0.07) | 4 (0.05) | 1 (0.01) | 0 (0.00) | 0 (0.00) | 0.0046 |
| Pulmonary Fibrosis | 9 (0.16) | 3 (0.04) | 9 (0.10) | 9 (0.06) | 11 (0.11) | 0.93 |
| Pulmonary Hypertension | 2 (0.03) | 5 (0.06) | 11 (0.11) | 9 (0.06) | 6 (0.06) | 0.99 |
| Retinal change or optic atrophy | 1 (0.02) | 4 (0.05) | 4 (0.04) | 5 (0.03) | 2 (0.02) | 0.93 |
| Ruptured Tendon | 1 (0.02) | 3 (0.03) | 5 (0.05) | 3 (0.02) | 4 (0.04) | 0.63 |
| Seizures requiring therapy for at least 6 months | 4 (0.07) | 1 (0.01) | 4 (0.04) | 1 (0.01) | 1 (0.01) | 0.038 |
| Valvular Disease | 2 (0.03) | 2 (0.02) | 8 (0.08) | 5 (0.03) | 0 (0.00) | 0.19 |
1
PY=Person-years. The actual number of PY used to calculate rates for each damage item varies somewhat because follow-up after damage of that type occurs is not included.
2
Based on a logistic regression model treating LLDAS percentage as a quantitative predictor.