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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Sep 24;70(11):1732–1744. doi: 10.1002/art.40578

Figure 3.

Figure 3

Antigen-experienced RF and ACPA B cells differ in class-switch and somatic hypermutation rates. (A) Proportion of antigen-experienced (i.e. unswitched (IgM/D) and class-switched (IgG/A/E) memory, double negative memory, and antibody-secreting) B cells for each antigen specificity. (B) Class-switch rates for antigen-experienced ACPA, RF, and Tet− B cells in RA patients, adjusting for subset differences and patient variability using a generalized linear mixed model. Error bars indicate 95% confidence intervals. * = P<0.05; ** = P<0.01; n.s. = not significant (C) Somatic mutation rates for antigen-experienced ACPA, RF, and Tet- B cells by subtype. Error bars indicate mean ± SEM. ** = P<0.01 (D) Somatic mutation rates for the immunoglobulins expressed by ACPA, RF, and Tet− B cells adjusting for subset differences and patient-to-patient variability using a linear mixed model. Error bars indicate 95% confidence intervals. *** = P<0.001; n.s. = not significant

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