Worms expressing α-synuclein:YFP in body wall muscle exhibit increased sensitivity to osmotic stress (A, 500 mM NaCl), heat stress (B, 37°C) and oxidative stress (C, 2 mM paraquat). D. All of these stresses were found to increase the accumulation of α-synuclein:YFP. Punc-54::α-syn:YFP worms are indicated as BW-asyn:YFP. Error bars indicate SEM. *p<0.05, ***p<0.001.