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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Exp Neurol. 2018 Aug 29;310:22–32. doi: 10.1016/j.expneurol.2018.08.013

Fig. 5.

Fig. 5.

Fimasartan inhibited ICH-induced expression of NLRP3 inflammasome mRNA and release of pro-inflammatory cytokines. Twenty-four hours after intracerebral hemorrhage (ICH), the mRNA expression of NLRP3 (A), ASC (B), and caspase-1 (C) and the release of pro-inflammatory cytokines IL-1β (D) and TNF-α (E) were higher in the control group than in the sham group. 30-day administration of low-dose fimasartan reduced the expression of NLRP3 mRNA and subsequent release of cytokines. The RT-PCR results are expressed as a fold change relative to the control group. Data are presented as the mean ± SEM from three independent experiments. n = 5 per group; * p < .05, *** p < .001.