Table 1.
Selected Characteristics of the Study Population
| Mean ± SD or n (%) | |
|---|---|
|
| |
| N | 393 |
|
| |
| Age –years | 51±11 |
|
| |
| Gender - male | 127 (32%) |
|
| |
| Race - white | 314 (80%) |
|
| |
| Ethnicity - Hispanic | 49 (13%) |
|
| |
| LABORATORY | |
|
| |
| AST (U/L) | 49±37 |
|
| |
| ALT (U/L) | 64±44 |
|
| |
| Alkaline phosphatase (U/L) | 83±32 |
|
| |
| GGT (U/L) | 70±83 |
|
| |
| Bilirubin, total (mg/dL) | 0.7±0.6 |
|
| |
| International normalized ratio | 1.04±0.13 |
|
| |
| Platelet count (1000 cells/uL) | 235±72 |
|
| |
| METABOLIC FACTORS | |
|
| |
| Body mass index (kg/m2) | 34.4±6.4 |
| Diabetes | 170 (44%) |
| Severe obesity (BMI ≥35 kg/m2) | 163 (42%) |
| Dyslipidemia | 221 (57%) |
|
| |
| HISTOLOGY | |
|
| |
| Ballooning mean grade | 0.9±0.8 |
| Grade 0 | 143 (36%) |
| Grade 1 | 132 (34%) |
| Grade 2 | 118 (30%) |
|
| |
| Lobular inflammation – mean grade | 1.6±0.7 |
| Grade 0 | 5 (1%) |
| Grade 1 | 211 (54%) |
| Grade 2 | 130 (33%) |
| Grade 3 | 47 (12%) |
|
| |
| Steatosis - mean grade | 1.8±0.9 |
| Grade 0 | 19 (5%) |
| Grade 1 | 150 (38%) |
| Grade 2 | 119 (30%) |
| Grade 3 | 105 (27%) |
|
| |
| NAFLD Activity Score (NAS) | 4.3±1.7 |
|
| |
| Portal inflammation - mean grade | 1.2±0.6 |
| Grade 0 | 45 (11%) |
| Grade 1 | 234 (60%) |
| Grade 2 | 114 (29%) |
|
| |
| Fibrosis – mean stage | 1.7±1.3 |
|
| |
| Stage 0 | 94 (24%) |
|
| |
| Stage 1 | 99 (25%) |
|
| |
| Stage 2 | 73 (19%) |
|
| |
| Stage 3 | 91 (23%) |
|
| |
| Stage 4 | 36 (9%) |
|
| |
| Definite NASH | 225 (57%) |
|
| |
| Time from biopsy to VCTE absolute value (days) – | |
|
| |
| Mean±SD | 64±64 |
|
| |
| Median [IQR] | 49 [25, 78] |