Table 2.

Cox Regression Analysis for Persistent Kidney Injury

	Univariable			Multivariable
	HR	95% CI	P	HR	95% CI	P
Age per Year	1.02	0.96 – 1.09	0.46
Female Sex	1.25	0.48 – 3.25	0.65
Autoimmune1	0.35	0.05 – 2.67	0.31
NASH	4.07	1.44 – 11.47	0.008
BMI per 1 kg/m2	1.05	0.97 – 1.13	0.24
Refractory Ascites	2.20	0.80 – 5.99	0.13
Any Hepatic Encephalopathy	1.89	0.67 – 5.35	0.23
Hypertension	2.12	0.84 – 5.39	0.11
Diabetes Mellitus	3.03	1.19 – 7.71	0.02
Albumin per 1 mg/dL	0.95	0.69 – 1.31	0.74
Baseline Creatinine per 1 mg/dL	3.00	1.75 – 5.13	<0.001	2.96	1.62 – 5.44	<0.001
Delta Creatinine per 1 mg/dL	2.11	1.67 – 2.68	<0.001	2.05	1.61 – 2.62	<0.001
Baseline Creatinine Group	5.61	2.16 – 14.57	<0.001
MDRD4 eGFR per 1 ml/min/1.73 m2	0.96	0.94 – 0.99	0.001
CKD-EPI eGFR per 1 ml/min/1.73 m2	0.95	0.93 – 0.97	<0.001
MELD-Na per 1 point	1.14	1.06 – 1.24	0.001
Child Pugh Score	1.25	0.97 – 1.61	0.09
Serum Na per 1 mmol/L	0.96	0.85 – 1.09	0.54
Total Bilirubin per 1 mg/dL	1.04	0.88 – 1.23	0.62
INR per 1 Unit	0.86	0.23 – 3.19	0.82
Equivalent dose of Furosemide per 25 mg	0.89	0.64 – 1.26	0.52
Equivalent dose of Spironolactone per 25 mg	1.07	0.86 – 1.34	0.55

¹Combined Autoimmune Hepatitis, Primary Sclerosing Cholangitis, and Primary Biliary Cholangitis; Hepatitis C (HCV); Non-Alcoholic Steatohepatitis (NASH); Hepatitis B (HBV); Modification of Diet in Renal Disease (MDRD); Estimated Glomerular Filtration Rate (eGFR); Sodium (Na); International Normalized Ratio (INR); Model for End-Stage Liver Disease with Serum Sodium (MELDNa)