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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Apr 26;11(2):e1523. doi: 10.1002/wnan.1523

Figure 9. OMVs functionality in vaccination and drug delivery.

Figure 9

Left: A. Natural derived OMVs vaccine formulas, including OMVs alone, OMVs combined with adjuvants, OMVs combined with bacterial antigens and AuNPs loaded OMVs; B. Bioengineered OMVs vaccine formula. Bacterial antigens are expressed as fusion proteins with outer membrane proteins located on the outer membrane surface of OMVs; Right: A. Directing enzyme packing delivery systems for packing PTE enzymes in OMVs; B. siRNA loaded bioengineered OMVs in cancer therapy.