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. 2018 Sep 6;16(4):234–243. doi: 10.1016/j.gpb.2018.07.002

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Examples of genes showing the difference in Shannon entropy between cell lines or developmental stages

A.LPCAT2, a gene related to inflammatory reactions, exhibits similar DNA methylation levels but different Shannon entropy values among three human cell lines including K562, GM12878, and HepG2. B.INSIG1, a gene related to cholesterol metabolism, exhibits similar DNA methylation levels but different Shannon entropy values among three human cell lines including K562, GM12878, and HepG2. C.Mocs1, a mouse gene related to the biosynthesis of molybdenum cofactor, exhibits different Shannon entropy values during the development of mouse heart. Data in embryos of 12.5 and 14.5 days were not shown due to the low quality. Error bars that represent the standard errors of the mean values were calculated with bootstrapping and P values were calculated from permutation test. ^***indicates a significant difference in DNA methylation level or heterogeneity between different samples (P < 0.001). LPCAT2, lysophosphatidylcholine acyltransferase 2; INSIG1, insulin induced gene 1; Mocs1, molybdenum cofactor biosynthesis protein 1.