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. 2018 Oct 26;8:15874. doi: 10.1038/s41598-018-34165-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan Meier curves for malignant transformation. Upper panel. Progression-free proportion by dysplasia grade including (left) and excluding (right) malignant transformation within 6 months of diagnosis of the index lesion (dysplasia grades green, none; blue, mild; amber, moderate; red, severe). Lower panel. Progression-free proportion by DNA ploidy status including (left) and excluding (right) transformation within 6 months of diagnosis of the index lesion (ploidy diagnosis green, diploid; blue, tetraploid; red, aneuploid). The number of patients still at risk at selected time points (x-axis) is shown below each plot. The difference in time to progression for different grades and DNA ploidy status were statistically significant, log rank test p ≤ 0.001.