Table 4.
Cox proportional hazards model on association of dysplasia grade and ploidy status with malignant progression.
| Including transformation within 6 months of index lesion (n = 228) | Excluding transformation within 6 months of index lesion (n = 219) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Univariate | Multivariate | n | Univariate | Multivariate | ||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| DYSPLASIA | No | 121 | 1.00 | — | 1.00 | — | 121 | 1.00 | — | 1.00 | — |
| Mild | 47 | 5.13 (0.46, 56.6) | 0.182 | 3.81 (0.33, 43.96) | 0.284 | 47 | 5.03 (0.46, 55.7) | 0.187 | 3.90 (0.33, 45.4) | 0.278 | |
| Mod | 32 | 29.64 (3.6, 243.6) | 0.002 | 18.78 (2.1, 167.9) | 0.009 | 30 | 21.57 (2.49, 186.8) | 0.005 | 14.11 (1.45, 137.3) | 0.023 | |
| Sev | 28 | 81.82 (10.5, 635.9) | 0.000 | 54.25 (6.6, 448.2) | 0.000 | 21 | 45.79 (5.52, 379.6) | 0.000 | 30.56 (3.37, 277.4) | 0.002 | |
| DNA PLOIDY | Dip | 183 | 1.00 | — | 1.00 | — | 180 | 1.00 | — | 1.00 | — |
| An | 42 | 7.92 (3.45, 18.17) | 0.000 | 2.41 (0.89, 6.52) | 0.083 | 36 | 6.79 (2.56, 17.9) | 0.000 | 2.39 (0.72, 7.98) | 0.155 | |
HR: hazard ratio. Univariate: adjusted for age, sex. Multivariate: adjusted for age, sex and mutually adjusted between dysplasia grade and ploidy status. Mod = moderate; Sev = severe; Dip = diploid; An = aneuploid.