Fig. 3.

Promoter histone PTM states are direction-specific. a A heatmap representing chromatin states learned for each species via a multivariate Gaussian Hidden Markov Model. Each state is a multivariate Gaussian distribution and is represented here via the mean scaled ChIP-Seq signal. Gray boxes indicate the state was not detected in the respective organism. P1/2/3: Promoter1/2/3, EL1/2: Transcription elongation1/2, E1/2: Enhancer1/2, me1: H3K4me1, me2: H3K4me2, Bkgd: Background. b Chromatin state positional coverage for promoters with stringently selected forward and reverse TSSs. c Partial-correlation analysis between promoter histone PTMs ChIP-Seq signal in forward and reverse directions for the same promoter NDRs (see Supplementary Table 2 for full partial-correlation table)