Fig. 3.

Sequence-specific blocking effect and alanine scanning of D1S peptide. a KM12SM cells were treated with IL-13 in the presence of two D1 peptides (long and short sequence) and two unrelated IL13Rα2 peptides and subjected to cell adhesion, invasion and MTT assays. Cell adhesion, invasion or proliferation triggered by IL13 (***p < 0.001) were inhibited by the presence of the indicated peptides (◊p < 0.05; ◊◊p < 0.01; ◊◊◊p < 0.001). b For testing alanine scanning, invasion assays of IL-13-treated KM12SM cells in the presence of the alanine-mutated D1S peptides were performed