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. 2018 Oct 26;8:15869. doi: 10.1038/s41598-018-34119-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo wound-healing process. A 50.2-mm² size skin defect was created on the dorsum of diabetic db/db mice. (a) Representative photographs of wound healing with a 16-mm circular template after transplantations of the cell sheet at 0, 5, 7, 9, 11, and 13 days compared with the control. (b) Plot of the wound closure over time after hADSC sheet treatment (black) compared with the control (open). The LMM (linear mixed model) method was used to determine the wound size for confound symmetry covariance within mouse P-value with bonferroni correction. Each value represents the mean ± SD (n = 10). *P < 0.05 compared with the control.

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