Fig. 1. The inflammasome pathway is activated in the retina after single or repeat blast injury to the eye.

a Western blot of caspase-1 in sham, single injury, and repeat injury mice at 4 weeks after injury. b Quantification of cleaved to total caspase-1 showing an increase at 4 weeks in both single and repeat injury groups. c Quantification of IL-1α after single or repeat blast. IL-1α is increased at 4 weeks after a single blast and at both 2 and 4 weeks after a repeat blast. d Quantification of IL-1β after single or repeat blast showing an increase at 4 weeks after either injury. e Quantification of IL-18 after single or repeat blast showing a transient increase at 2 weeks after injury for both groups. This experiment was repeated twice. n = 5 for all groups. **p < 0.01, ***p < 0.001, ^#p < 0.0001