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. 2018 Oct 26;9:4463. doi: 10.1038/s41467-018-07003-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — ESP22 suppresses sexual receptivity of virgin female mice. a Timeline for sexual behavior assays using adult female mice pre-exposed to either ESP22 or control buffer. b Raster plot representing mounting episodes made by the male mouse, with cyan and magenta bars representing attempts associated with lordosis or rejection responses, respectively, by C57BL/6J female mice. Mounting attempts without lordosis or rejection are represented with grey bars. Control buffer-exposed female mice, n = 16; ESP22-exposed female mice, n = 13. c Quantification of the sexual behaviors of control buffer- and ESP22-exposed female mice. Each dot represents data of an individual female mouse. d Timeline for the sexual behavior assays using C57BL/6J adult female mice pre-exposed to either C3H/HeJ (C3H, ESP22-) or C57BL/6J (B6, ESP22+) juvenile mice. e, f Raster plots and quantification are the same as detailed in b, c. C3H juvenile-exposed female mice, n = 7; B6 juvenile-exposed female mice, n = 9. Error bars, S.E.M. **p < 0.01 and *p < 0.05 by Wilcoxon rank sum test with Holm correction