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. 2018 Oct 26;8:15837. doi: 10.1038/s41598-018-34030-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antitumor effect of anti-angiogenic drugs in the zebrafish embryos. Tumor inhibition effect of three anti-angiogenic drugs in an A549 xenograft zebrafish model. Each compound was evaluated at three different concentrations: bevacizumab (28 ng, 83 ng and 250 ng per embryo), apatinib (0.057 μg/mL, 0.167 μg/mL and 0.5 μg/mL) and endostar (11 ng, 33 ng and 99 ng per embryo). (A) Lateral views of CM-Dil stained A549 cells in 5dpf zebrafish embryos treated with compound for 72 hours. (B) Fluorescence intensity values of A549 cells in zebrafish larvae. (C) Tumor growth inhibition rates is calculated as difference between fluorescence intensities in treated and control groups expressed as percentage of tumor fluorescence intensities in control zebrafish. All quantification data are presented as means ± SEM. P values were calculated with one-way ANOVA followed by Dunnett’s test, **p < 0.01, ***p < 0.001, #p > 0.05 compared to control.