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. 2018 Oct 26;8:15837. doi: 10.1038/s41598-018-34030-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antitumor activity of anti-angiogenesis alone and in combination with pemetrexed. On 2dpf, CM-Dil labeled A549 xenograft zebrafish embryos were treated with three anti-angiogenesis alone and in combination with pemetrexed for 3 days. Pemetrexed (P) (2 ng per embryo), bevacizumab (B) (28 ng per embryo) and endostar (E) (11 ng per embryo) were injected into embryos and apatinib (A) (0.5 μg/mL) was dissolved in breeding water. (A) Fluorescent images showing A549 xenograft zebrafish larvae at 5dpf treated with different inhibitors. (B) Quantification of fluorescence intensity of tumor. (C) Tumor growth inhibition rates were calculated according to the fluorescence intensities of tumor. Each bar represents the mean ± SEM. One-way ANOVA followed by Dunnett’s test, *p < 0.05, **p < 0.01, ***p < 0.001 when compared with control group.