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. 2018 Oct 26;8:15837. doi: 10.1038/s41598-018-34030-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gross morphological changes in the zebrafish larvae following anti-angiogenic compound exposure at 120 hpf. Wild-type zebrafish were collected at 6 hpf and were treated with bevacizumab (28 ng, 83 ng and 250 ng per embryo), endostar (11 ng, 33 ng and 99 ng per embryo) and apatinib (0.22 μg/mL, 0.67 μg/mL and 2 μg/mL dissolved in breeding water) at 28 °C until 120 hpf. Apatinib (0.67 µg/mL) treatment: pericardial edema (arrow); apatinib (2 µg/mL) treatment: pericardial edema (arrow), decreased eye size (arrowhead) and shortened body axis.