Table 2. Clinical data and status of Epstein-Barr virus and Merkel cell polyomavirus detection in 67 laryngeal cancer patients positive for at least one high-risk human papillomavirus.

Patient No.	Sex	Age	Surgical sample	Anatomical location	Histopathological grading	Smoking	Alcohol use	HR-HPV genotype	EBV	MCPV
7	M	61	Laryngectomy	Subglottic	MDSK	Yes	Yes	11, 52	–	–
8	M	75	Biopsy	Glottic	MDSK	Yes	No	52	–	–
9	M	53	Laryngectomy	Transglottic	MDSK	Yes	No	16	–	–
10	M	61	Biopsy	Glottic	MDSK	Yes	No	52	–	–
13	M	61	Biopsy	Supraglottic	MDSK	Yes	No	52	–	–
15	M	63	Biopsy	Glottic	MDSK	Yes	No	16	–	+
28	M	71	Laryngectomy	Transglottic	MDSK	Yes	No	11, 52	–	–
29	M	68	Biopsy	Supraglottic	MDSK	Yes	No	11, 16	–	–
32	M	69	Biopsy	Glottic	MDSK	Yes	No	45	–	+
45	M	81	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	+
46	M	67	Biopsy	Glottic	MDSK	Yes	No	11, 16	–	–
47	M	71	Laryngectomy	Transglottic	MDSK	Yes	No	6, 11, 52	–	–
49	M	63	Laryngectomy	Transglottic	MDSK	Yes	No	11, 52	–	–
50	M	68	Laryngectomy	Glottic	MDSK	No	Yes	11, 45, 52	–	–
51	M	83	Biopsy	Supraglottic	MDSK	Yes	No	6, 11, 52	–	–
52	M	66	Biopsy	Glottic	MDSK	Yes	No	16, 52	–	–
53	M	60	Laryngectomy	Transglottic	MDSK	Yes	No	11, 52	–	–
54	M	67	Biopsy	Glottic	HDI	Yes	No	45	–	–
55	M	69	Biopsy	Glottic	MDSK	Yes	No	6, 11, 52	–	–
56	M	60	Laryngectomy	Glottic	MDSK	Yes	No	11, 45	–	–
57	F	72	Biopsy	Glottic	HDI	Yes	No	11, 52	+	–
58	M	72	Laryngectomy	Glottic	MDSK	Yes	No	11, 52	–	–
59	M	51	Laryngectomy	Transglottic	MDSK	Yes	No	52	+	–
60	M	61	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	–
61	M	78	Biopsy	Glottic	MDSK	Yes	Yes	11, 16	–	–
62	M	61	Laryngectomy	Transglottic	MDSK	Yes	No	6, 11, 52	–	–
63	M	56	Laryngectomy	Subglottic	MDSK	Yes	No	11, 31, 52, 54	+	–
64	M	62	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	–
65	M	79	Biopsy	Glottic	MDSK	Yes	No	11, 52	+	–
66	M	84	Laryngectomy	Glottic	MDSK	Yes	No	6, 11, 52	–	–
67	M	55	Biopsy	Glottic	MDSK	Yes	No	6, 11, 52	+	–
68	M	65	Laryngectomy	Transglottic	MDSK	Yes	Yes	11, 16, 52	+	–
69	M	58	Laryngectomy	Transglottic	MDSK	Yes	No	11, 52	–	–
70	M	72	Laryngectomy	Transglottic	MDSK	No	No	11, 52	+	–
71	M	74	Laryngectomy	Transglottic	MDSK	Yes	No	11, 31, 52, 54	–	–
72	M	71	Laryngectomy	Transglottic	MDSK	Yes	No	11, 52	–	–
73	M	67	Laryngectomy	Glottic	MDSK	Yes	No	52	–	–
74	M	72	Laryngectomy	Supraglottic	MDSK	Yes	No	11, 31, 52, 54	+	–
75	M	84	Laryngectomy	Glottic	MDSK	Yes	No	11, 26, 31, 52, 54	+	–
79	M	70	Biopsy	Glottic	MDNK	Yes	No	11, 31, 52, 54	–	–
80	M	49	Biopsy	Glottic	HDI	Yes	No	11, 52	–	–
81	M	72	Laryngectomy	Glottic	MDSK	Yes	No	11, 31, 52, 54	–	–
84	M	56	Biopsy	Glottic	MDSK	Yes	No	6, 11, 16, 52	–	–
85	M	79	Biopsy	Supraglottic	MDSK	Yes	No	11, 52	–	–
86	M	63	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	–
88	M	68	Laryngectomy	Transglottic	MDSK	Yes	No	6, 11, 52	+	–
89	M	60	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	–
90	M	62	Laryngectomy	Transglottic	MDSK	Yes	No	11, 31, 52	+	–
91	M	75	Biopsy	Glottic	MDSK	Yes	No	11, 52	–	–
92	M	76	Laryngectomy	Transglottic	MDSK	Yes	No	11, 31, 52	–	–
97	M	49	Laryngectomy	Glottic	MDSK	Yes	No	52	–	–
99	M	67	Biopsy	Supraglottic	MDSK	Yes	No	52	–	–
102	M	63	Biopsy	Supraglottic	HDI	Yes	No	31, 52, 54	–	–
113	M	76	Biopsy	Glottic	MDSK	Yes	No	52	–	–
114	M	71	Biopsy	Glottic	MDSK	Yes	No	52	–	–
119	M	49	Biopsy	Transglottic	MDSK	Yes	No	45	+	–
120	M	77	Biopsy	Glottic	MDSK	Yes	No	45	+	–
124	F	75	Biopsy	Glottic	MDSK	Yes	No	45	–	–
133	M	63	Biopsy	Glottic	HDI	Yes	No	45	–	–
139	M	69	Biopsy	Glottic	MDSK	Yes	Yes	52	+	–
141	M	58	Biopsy	Glottic	MDSK	Yes	No	52	–	+
144	M	65	Biopsy	Glottic	HDI	Yes	No	31, 52	–	–
148	M	62	Biopsy	Glottic	MDSK	Yes	No	52	+	–
149	M	75	Biopsy	Glottic	MDSK	No	No	45	+	+
180	M	54	Biopsy	Glottic	MDSK	Yes	No	11, 16	–	–
184	M	64	Biopsy	Glottic	MDSK	Yes	No	11, 16, 40, 82	–	–
195	M	59	Biopsy	Glottic	MDNK	Yes	No	16	–	–

Notes.

HR-HPV

high-risk human papillomavirus

EBV

Epstein-Barr virus

MCPV

Merkel cell polyomavirus

Sex is indicated as M, male or F, female.

HDI

highly differentiated invasive

MDNK

moderately differentiated non-keratinized

MDSK

moderately differentiated some keratinized