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. Author manuscript; available in PMC: 2018 Oct 27.
Published in final edited form as: J Cardiovasc Pharmacol Ther. 2018 Mar 19;23(4):350–357. doi: 10.1177/1074248418763612

Figure 1.

Figure 1.

Effect of p53 inhibition on ischemia/reperfusion (I/R) injury. A, Experimental protocol (study using inhibitors). Myocardial infarction was induced by 20-minute global ischemia/2-hour reperfusion. Two types of p53 inhibitors (pifithrin-α and pifithrin-μ) were infused at the indicated doses and for the indicated time periods. B, Effects of p53 inhibitors on infarct size and functional recovery after I/R (study using inhibitors). Infarct size was expressed as a percentage of the left ventricular area. Rate pressure product (RPP) was calculated by multiplying left ventricular developed pressure (LVDP) by heart rate (HR). NS indicates not significant.