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Effect of genetic deletion of p53 on ischemia/reperfusion (I/ R) injury (knockout study). A, B Effects of genetic deletion of p53 on infarct size (A, B) and functional recovery (C) after I/R. Infarct size was expressed as a percentage of the left ventricular area. Rate pressure product (RPP) was calculated by multiplying left ventricular developed pressure (LVDP) by heart rate (HR). Hatched bar = Wild type (WT), open bar = p53 heterozygous knockout mice (p53+/−). *P < .05 vs. WT.
