. Author manuscript; available in PMC: 2018 Oct 27.

Published in final edited form as: J Cardiovasc Pharmacol Ther. 2018 Mar 19;23(4):350–357. doi: 10.1177/1074248418763612

Table 5.

Summary of the Literature Regarding Effects of p53 Inhibition on Acute Myocardial Ischemia/Reperfusion Injury.

	Species	Protocol of I/R Injury	Protocol of p53 Inhibition	Estimation of Infarct Size	Result	References

1	Male rats	Isolated perfused hearts, Regional I/R	Infusion of PFTα at 10 μmol/L, for 15 minutes before I, for 5 minutes prior to the end of I and continued for 10 minutes to R	TTC staining	IS reduction	²²
2	Male rabbits	In vivo, Regional I/R	Administration of PFTα at 1.5 or 3.0 mg/kg by intraperitoneal injection 30 minutes before I	TTC staining	1.5 mg/kg: no effect on IS, 3.0 mg/kg: IS reduction	²⁰
3	Aged male F344 rats (20 months old)	In vivo, Regional I/R	Administration of PFTa at 2.2 mg/kg by intraperitoneal injection 40 minutes before I	TTC staining	IS reduction	²¹
4	Male mice (11–14 weeks old)	Isolated perfused hearts Global I/R	As shown in Figure 1A	TTC staining	No effect on IS	Our study

Abbreviations: I/R, ischemia/reperfusion; PFT, pifithrin; TTC, 2,3,5-triphenyltetrazolium chloride, IS = infarct size.