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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Nature. 2018 Oct 15;562(7728):563–568. doi: 10.1038/s41586-018-0608-y

Figure 2. Evolution of a methionine-selective bioconjugation strategy.

Figure 2

(a) Initial results for functionalization at methionine with hypervalent iodine reagents. (b) Optimal process for the thiourea-accelerated methionine selective bioconjugation of exenatide.