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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Nature. 2018 Oct 15;562(7728):563–568. doi: 10.1038/s41586-018-0608-y

Figure 4. Exploiting the multi-faceted reactivity of the protein-sulfonium conjugate.

Figure 4

(a) A photocatalytic design plan for secondary protein diversification. (b) A system for photo-redox mediated reduction of the sulfonium conjugate and examples of the substrate scope; in the case of 17e, further reduction of C–S bond in 13 was not observed35. Interestingly, the reduction of 13 proceeds in light, without the Ir-photocatalyst, but the yield was greatly diminished. (c). Secondary protein functionalization via photoredox radical cross coupling between diazo sulfonium-protein conjugate and C-4 substituted Hantzsch ester.