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. Author manuscript; available in PMC: 2018 Oct 27.
Published in final edited form as: Mem Inst Oswaldo Cruz. 2012 Aug;107(5):571–577. doi: 10.1590/s0074-02762012000500001

Fig. 2:

Fig. 2:

a simplified schematic representation of the different expression patterns in the cervical epithelium. No staining was observed in the cervical epithelium of control specimens (A, B). Low-grade cervical intraepithelial neoplasia (CIN) showed a diffuse and intense staining pattern in the displasic area limited to the one-third basal layer of the epithelium (C, D). High-grade CIN showed an intense staining in all epithelium layers (E, F). The invasive tumour specimens showed an intense and diffuse staining with high frequency of p16INK4a positivity in neoplastic cells (G, H).