Table 1.
Baseline characteristics of treatment groups
| Characteristic | PMX-HP group (n = 29) | Non-PMX-HP group (n = 30) | P valuea |
|---|---|---|---|
| Age (years), mean (SD) | 70.2 (13.0) | 67.4 (14.6) | 0.43 |
| Male, n (%) | 23 (79) | 17 (57) | 0.06 |
| BMI (kg/m2), mean (SD) | 24.2 (4.3) | 23.5 (4.7) | 0.62 |
| Baseline serum creatinine (mg/dl), median (Q1, Q3) | 1.0 (1.0, 1.1) | 1.0 (0.8, 1.1) | 0.48 |
| BUN at enrollment (mg/dl), median (Q1, Q3) | 41 (26, 63) | 41 (22, 62) | 0.65 |
| Serum creatinine at enrollment (mg/dl), median (Q1, Q3) | 2.2 (1.6, 3.1) | 2.6 (1.8, 4.0) | 0.34 |
| AKI, n (%) | 0.16 | ||
| Non-AKI | 4 (14) | 5 (17) | |
| Stage 1 | 8 (28) | 4 (13) | |
| Stage 2 | 9 (31) | 5 (17) | |
| Stage 3 | 8 (28) | 16 (53) | |
| RRT, n (%) | 27 (93) | 20 (69) | 0.02 |
| CRRT | 21 (72%) | 14 (48%) | |
| SLED | 6 (21%) | 4 (14%) | |
| Peritoneal dialysis | 0 (0%) | 2 (7%) | |
| SOFA score, mean (SD) | 13.8 (4.4) | 13.3 (5.0) | 0.71 |
| Type of fluid, n (%) | |||
| Crystalloid | 23 (79) | 23 (77) | 0.81 |
| Colloid | 15 (52) | 13 (43) | 0.52 |
| Inotrope/vasopressor use, n (%) | 25 (86) | 25 (83) | > 0.99 |
| Adrenaline | 8 (28) | 6 (20) | 0.49 |
| Noreadrenaline | 20 (69) | 22 (73) | 0.71 |
| Dopamine | 8 (28) | 4 (13) | 0.17 |
| Dobutamine | 4 (14) | 3 (10) | 0.71 |
| Vasopressin | 0 (0) | 0 (0) | > 0.99 |
| Terlipressin | 1 (3) | 0 (0) | 0.49 |
| Inotropic score (μg/kg/min), median (Q1, Q3) | 36 (7, 70) | 30 (2, 83) | 0.96 |
| Vasopressor index (μg/kg/min/mmHg), median (Q1, Q3) | 0.4 (0.1, 1.1) | 0.4 (0.1, 1.1) | 0.93 |
| EAA at enrollment, median (Q1, Q3) | 0.8 (0.7, 1.0) | 0.7 (0.7, 0.9) | 0.24 |
| Presepsin (pg/ml), median (Q1, Q3) | 5514 (4088, 10,513) | 5030 (2459, 10,734) | 0.47 |
Data represent sample size and column percentage unless otherwise noted
PMX-HP polymyxin B hemoperfusion, SD standard deviation, BMI body mass index, Q1 25th percentile, Q3 75th percentile, BUN blood urea nitrogen, AKI acute kidney injury, RRT renal replacement therapy, CRRT continuous renal replacement therapy, SLED sustained low-efficiency dialysis, CVS SOFA cardiovascular Sequential Organ Failure Assessment, EAA endotoxin activity assay
aFisher’s exact test for categorical variables; Student’s t test or Kruskal–Wallis test for continuous variables, Italic data represent P value statistically significant