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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Hepatology. 2018 Jul 16;68(6):2078–2088. doi: 10.1002/hep.29921

Table 2.

Selected pathways with greatest proportion of downregulated genes comparing baseline and on-treatment liver biopsies in gene ontology enrichment analysis of global mRNA expression.

Gene Pathway Proportion of downregulated
genes
[%]		 P-Value
Type I interferon signaling pathway 37 <10−9
Interferon alpha/beta signaling 31 <10−9
Response to type I interferon 27 <10−9
Type II interferon signaling (IFNG) 26 <10−9
Interferon-gamma-mediated signaling pathway 25 <10−9
Negative regulation of viral genome replication 22 <10−9
Interferon gamma signaling 22 <10−9
Cellular response to type I interferon 21 <10−9
Cellular response to interferon-gamma 21 <10−9
Response to interferon-gamma 21 <10−9