Table 5.
RETN haplotype frequencies in healthy controls and OSCC patients.
| Haplotype block | Controls | Patients | |||||
|---|---|---|---|---|---|---|---|
| rs3745367 G/A | rs7408174 T/C | rs1862513 G/C | rs3219175 G/A | n = 2400 | n = 1870 | OR (95% CI) | AOR (95% CI)a |
| G | T | G | G | 679 (28.3%) | 492 (26.3%) | 1.000 (reference) | 1.000 (reference) |
| G | C | G | G | 475 (19.8%) | 422 (22.6%) | 1.226 (1.029-1.461)b | 1.212 (0.965-1.522) |
| A | T | C | A | 318 (13.2%) | 291 (15.6%) | 1.263 (1.037-1.538)c | 1.150 (0.890-1.486) |
| A | T | G | G | 257 (10.7%) | 226 (12.1%) | 1.214 (0.981-1.502) | 1.376 (1.039-1.823) g |
| A | T | C | G | 189 (7.9%) | 153 (8.2%) | 1.117 (0.876-1.424) | 1.219 (0.890-1.672) |
| G | T | C | G | 191 (8.0%) | 146 (7.8%) | 1.055 (0.826-1.347) | 1.062 (0.773-1.460) |
| G | T | C | A | 67 (2.8%) | 57 (3.0%) | 1.174 (0.810-1.703) | 1.051 (0.644-1.716) |
| A | C | C | A | 86 (3.6%) | 36 (1.9%) | 0.578 (0.385-0.867)d | 0.712 (0.427-1.188) |
| G | C | C | G | 63 (2.6%) | 30 (1.6%) | 0.657 (0.419-1.031) | 0.889 (0.509-1.552) |
| A | C | G | G | 46 (1.9%) | 14 (0.7%) | 0.420 (0.228-0.773)e | 0.343 (0.161-0.728)h |
| A | C | C | G | 19 (0.8%) | 1 (0.1%) | 0.073 (0.010-0.544)f | 0.176 (0.019-1.643) |
| G | C | C | A | 6 (0.2%) | 0 (0.0%) | - | - |
| A | T | G | A | 2 (0.1%) | 2 (0.1%) | 1.380 (0.194-9.831) | 1.620 (0.105-24.958) |
| G | C | G | A | 2 (0.1%) | 0 (0.0%) | - | - |
aMultivariate analysis adjusted for the effects of betel quid chewing, tobacco smoking, and alcohol consumption.
b p=0.0225; cp=0.0201; dp=0.0081; ep=0.0053; fp=0.0107; gp=0.0258; hp=0.0054.
OSCC: oral squamous cell carcinoma; OR: odds ratio; AOR: adjusted odds ratio.