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SPR aborted the aggregated oxidative stress induced by aldosterone in a myocardioblast cell line. (a–c) Gene expression of GCLC, NRF-1, and Nox4 in H9C2 cells treated with aldosterone (10−7 mmol/L), with or without SPR (10−7 mol/L), for 72 h. (d) Cellular ROS levels after treatment with aldosterone, with or without SPR. N = 3, data are shown as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. control group; ##P < 0.01 and ###P < 0.001 vs. aldosterone-treated group.
