Table 3.
Basic characteristics of Sprague-Dawley rats.
| NDC (n = 8) | STZ + NS (n = 8) | STZ + SPR (n = 8) | P values | |
|---|---|---|---|---|
| BW (g) | 527.10 ± 8.61 | 218.90 ± 7.65∗∗∗∗ | 189.10 ± 10.98∗∗∗∗ | <0.0001 |
| BG (mM) | 6.26 ± 0.32 | 32.69 ± 0.41∗∗∗∗ | 30.50 ± 1.14∗∗∗∗ | <0.0001 |
| SBP (mm Hg) | 136.10 ± 1.82 | 147.50 ± 5.38 | 145.50 ± 6.33 | >0.05 |
| DBP (mm Hg) | 81.13 ± 5.25 | 81.43 ± 5.39 | 77.82 ± 3.70 | >0.05 |
| HW (g) | 1.94 ± 0.09 | 1.35 ± 0.12∗∗∗∗ | 1.29 ± 0.17∗∗∗∗ | <0.0001 |
| HW/BW (mg/g) | 3.94 ± 0.22 | 6.68 ± 0.70∗∗∗∗ | 7.22 ± 1.12∗∗∗∗ | <0.0001 |
NDC: nondiabetic controls; STZ: streptozotocin; NS: saline; SPR: spironolactone; BW: body weight; BG: blood glucose; SBP: systolic blood pressure; DBP: diastolic blood pressure; HW: heart weight; HW/BW: heart weight/body weight. N = 8, data are means ± SEM. ∗P < 0.05 and ∗∗∗∗P < 0.0001 vs. NDC group.