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. 2018 Oct 14;2018:1061276. doi: 10.1155/2018/1061276

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Copyright © 2018 Marcella Nebbioso et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Some signs of pathology improvement 3 months after the start of CY (cyclosporine) therapy, such as TFT (tear ferning test), baseline 2.43 (±0.80 SD) score, and posttherapy 1.93 (±0.67) score (p=0.044) (a); density of conjunctival goblet cells, baseline 30 (±20 SD) cells/field, and posttherapy 23 (±8 SD) cells/field (p=0.044) (b). There are no changes in the MUC5AC levels before (4,103.33 ± 286.35 SD pg/ml) and after therapy (3,909.18 ± 606.01 SD pg/ml) (c), even because a 3-month treatment period is too short to evaluate the possible functional improvement of the conjunctiva in patients with chronic VKC (vernal keratoconjunctivitis).