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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Nature. 2018 Aug 29;561(7721):137–140. doi: 10.1038/s41586-018-0454-y

Figure 2 |. The Pick tau filament fold.

Figure 2 |

a, Sharpened, high-resolution cryo-EM map of the narrow Pick filament (NPF) with the atomic model of the Pick fold overlayed. b, Schematic view of the Pick fold. Amino acid numbering corresponds to the 441 amino acid human tau isoform, so residues 275–305 of R2 are not present.