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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Nature. 2018 Aug 29;561(7721):137–140. doi: 10.1038/s41586-018-0454-y

Figure 3 |. Comparison of the Pick and Alzheimer tau filament folds.

Figure 3 |

a, Sequence alignment of the microtubule-binding repeats (R1-R4) with the observed nine β-strand regions (arrows) in the Pick fold and eight β-strand regions (arrows) in the Alzheimer fold, coloured from violet to red. b, Rendered view of the secondary structure elements in the Pick fold, depicted as three successive rungs. c, As in b, but in a view perpendicular to the helical axis, revealing the changes in height within a single molecule. d, Schematic of the secondary structure elements in the Pick and Alzheimer folds, depicted as a single rung. The positions of C322 and D348 in the two folds are highlighted. The symbols ‡ and * mark conserved turns of homologous regions in the Pick and Alzheimer folds.