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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Nature. 2018 Aug 29;561(7721):137–140. doi: 10.1038/s41586-018-0454-y

Figure 6 |. Immunoblot analysis of additional Pick’s disease cases.

Figure 6 |

a, Diagram of 2N4R tau showing the N-terminal inserts (N1, N2), the repeats (R1-R4) and the epitopes of antibodies BR133 (N-terminus), BR136 (R1), Anti-4R (R2), BR135 (R3), TauC4 (R4) and BR134 (C-terminus). b, Immunoblots of epitope-deletion recombinant tau constructs with the antibodies shown in a. Identical results were obtained in two independent repeats. c, Immunoblots using the antibodies BR136, Anti-4R, BR135 and TauC4 of tau filaments extracted from the frontotemporal cortex of 9 patients with Pick’s disease (patient 4 was used for cryo-EM). See Extended Data Table 1 for details of Pick’s disease patients.