Extended Data Table 1 |. Summary of Pick’s disease patients.
Wild-type (wt) means that no known disease-causing mutations in the tau gene (MAPT) or the presenilin-1 gene (PSEN1) were detected. The patient used for cryo-EM is highlighted in yellow.
| Patient | Gender | Age at death (years) | MAPI | PSEN1 | APOE haplotypes | Post-mortem interval (h) |
|---|---|---|---|---|---|---|
| 1 | F | 73 | wt | wt | E3/E3 | 23.8 |
| 2 | F | 70 | wt | wt | ɛ3/ɛ3 | 20.5 |
| 3 | M | 61 | wt | wt | ɛ3/ɛ4 | 24.5 |
| 4 | F | 63 | wt | wt | ɛ2/ɛ3 | 3.0 |
| 5 | M | 70 | wt | wt | ɛ3/ɛ3 | 14.0 |
| 6 | M | 65 | wt | wt | ɛ3/ɛ3 | 12.5 |
| 7 | M | 64 | wt | wt | ɛ3/ɛ4 | 3.0 |
| 8 | M | 56 | wt | wt | ɛ3/ɛ4 | 9.0 |
| 9 | M | 69 | wt | wt | ɛ3/ɛ4 | 4.5 |