. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Ophthalmic Epidemiol. 2017 Oct 16;25(1):79–88. doi: 10.1080/09286586.2017.1362009

Table 2.

Spearman correlation coefficients^* among plasma homocysteine level and dietary intake (food + supplements) of folate, vitamin B₆, vitamin B₁₂, choline, and betaine in Physicians’ Health Study II.


	Plasma tHcy	Dietary folate	Dietary B₆	Dietary B₁₂	Dietary choline	Dietary betaine


a) cases + controls, n=292
Plasma tHcy	1.0
Dietary folate	−0.10	1.0
Dietary B₆	−0.09	0.83^§	1.0
Dietary B₁₂	−0.19^‡	0.53^§	0.66^§	1.0
Dietary choline	−0.07	0.02	0.19^†	0.36^§	1.0
Dietary betaine	−0.10	0.27^§	0.21^‡	0.06	0.06	1.0
b) cases, n=146
Plasma tHcy	1.0
Dietary folate	−0.05	1.0
Dietary B₆	−0.06	0.83^§	1.0
Dietary B₁₂	−0.24^†	0.46^§	0.60^§	1.0
Dietary choline	−0.05	0.08	0.23^†	0.36^§	1.0
Dietary betaine	−0.02	0.23^†	0.16	0.02	0.16	1.0
c) controls, n=146
Plasma tHcy	1.0
Dietary folate	−0.13	1.0
Dietary B₆	−0.08	0.82^§	1.0
Dietary B₁₂	−0.14	0.60^§	0.72^§	1.0
Dietary choline	−0.07	−0.04	0.14	0.36^§	1.0
Dietary betaine	−0.16	0.30^‡	0.24^†	0.09	−0.02	1.0

Abbreviations: tHcy, homocysteine

Adjusted for age

^†

p<.01

^‡

p<.001

^§

p<.0001