. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Ophthalmic Epidemiol. 2017 Oct 16;25(1):79–88. doi: 10.1080/09286586.2017.1362009

Table 3.

Multivariable-adjusted OR (95% CI) of AMD according to quartile of plasma homocysteine (146 case-control pairs) in Physicians’ Health Study II.

	Quartile				P (trend)
	1	2	3	4	P (trend)

Median (range), μmol/L	10.9 (9.5–12.1)	13.0 (12.2–13.9)	14.6 (14.0–16.0)	19.3 (16.2–66.7)
Cases/Controls	30/36	42/35	31/38	43/37
Model 1, OR (95% CI)	1.0	1.41 (0.71–2.82)	0.88 (0.44–1.77)	1.29 (0.66–2.55)	0.78
Model 2, OR (95% CI)	1.0	1.10 (0.51–2.35)	0.78 (0.36–1.68)	1.09 (0.52–2.31)	0.99

Abbreviations: OR, odds ration; CI, confidence interval; AMD, age-related macular degeneration.

Model 1 – Control for matching factors (age, smoking, time of blood draw).

Model 2 – Model 1 plus control for alcohol use (rarely/never, ≥1 drink/month), BMI (kg/m2), current exercise (≥1 time/wk),, history of high cholesterol (self-reported total cholesterol level of at least 240 mg/dL, or past or current treatment for high cholesterol), history of diabetes, and randomized treatment assignment (vitamin E, vitamin C, beta carotene, multivitamins).