Skip to main content
. Author manuscript; available in PMC: 2019 Sep 21.
Published in final edited form as: Org Lett. 2018 Sep 13;20(18):5918–5921. doi: 10.1021/acs.orglett.8b02584

Figure 4.

Figure 4.

Post-enediyne PKS tailoring steps for TNM A (1) biosynthesis in S. sp. CB03234 enabled the formulation of a unified biosynthetic pathway for all members of the family of anthraquinone-fused enediynes, DYN (4) in M. chersina, TNM (1), UCM (2) in S. uncialis, and YPM (3) in M. yangpuensis, featuring 26 as a key common intermediate. Groups transformed in each of the tailoring steps are highlighted in red. Intermediates in brackets are not isolated. Dashed arrows indicate shunt metabolites isolated.