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Cytotoxicity (IC50s in nM) of the Five New Enediynes (5, 6, 12, 13, 20), in comparison with TNM A (1), against Five Selected Human Cancer Cell Lines
| cell line | SF-295 | SKMEL-5 | MDA-MB-231 | SKBR-3 | NCI-H226 |
|---|---|---|---|---|---|
| 1 | 0.83 ± 0.07 | 0.56 ± 0.12 | 1.0 ± 0.4 | 0.90 ± 0.19 | 17 ± 1 |
| 5 | 51 ± 9 | 22 ± 1 | 29 ± 1 | 22 ± 1 | >100 |
| 6 | 2.2 ± 0.1 | 2.5 ± 0.1 | 2.1 ± 0.3 | 1.7 ± 0.1 | 31 ± 6 |
| 12 | 16 ± 2 | 13 ± 3 | 17 ± 3 | 14 ± 1 | >100 |
| 13 | 8.0 ± 0.8 | 9.1 ± 1.6 | 8.4 ± 1.9 | 6.8 ± 0.2 | >100 |
| 20 | 52 ± 2 | 24 ± 6 | 35 ± 4 | 16 ± 3 | >100 |
