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. 2018 Oct 27;16:106. doi: 10.1186/s12958-018-0426-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mangafodipir rescues follicles from anticancer drug-induced oxidative stress. a Representative images of immunohistochemistry for 4-HNE in ovaries treated with 7.5 (CIS7.5) or 20 (CIS20) mg/kg cisplatin, or 7.5 (PTX7.5) or 20 (PTX20) mg/kg paclitaxel, with or without mangafodipir (+/− Mangafodipir, respectively). Bar, 100 μm. b 4-HNE immunoreactive intensity scores. Mean ± SD, *, p < 0.05. c Mangafodipir (m.10 mg/kg) reduced 4-HNE induced by 7.5 (CIS7.5), 20 (CIS20) mg/kg cisplatin, 7.5 (PTX7.5) or 20 (PTX20) mg/kg paclitaxel. The relative intensities of 4-HNE signals were normalized to those of β-actin to assess the results of the immunoblot in mice ovaries. Mean ± SEM, *, p < 0.05 vs. each control (m0)