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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Int J Cancer. 2018 Mar 30;143(4):921–930. doi: 10.1002/ijc.31374

Fig. 2. Chemo- and radiation-sensitivities of CASP3KO HCT116 & shCASP3 HT29 colon cancer cells.

Fig. 2.

(a) Clonogenic assay results for vector control and CASP3KO HCT116 cells exposed to different concentrations mitomycin C. (b) Clonogenic assay results for vector control and CASP3KO HCT116 cells exposed to different doses of X rays. (c and d) Clonogenic assay results of control and HT29shCASP3 cells treated with different concentrations of mitomycin C (c) and different doses of X rays (d). (e)Tumor growth from control and CASP3KO HCT116 cells inoculated (at 1×10 cells/mouse) in nude mice with or without radiotherapy (2×8Gy of X rays). P<0.05, n=5 per group, Student’s t test. Error bars represent SEM. (f)Kaplan Meier survival curve of mice inoculated with control and CASP3KO HCT116 cells and treated with or without X rays, *P<0.001, log rank test, n=5. Lack of survival was defined as tumor volume ≥2,000 mm3 or when mice were sacrificed because they are moribund.