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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Dev Neurobiol. 2018 Jun 14;78(10):960–977. doi: 10.1002/dneu.22605

Fig. 5. Axon growth response produced by pro-regenerative TFs correlates with accessibility of target genes.

Fig. 5

Pie charts represent percent promoter accessibility of pro-regenerative TF targets across age (green-accessible; red – inaccessible) (A) Promoters of KLF6 and Sox11 targets are accessible in adult neurons (KLF6 - 95% open in P0 to 90% open in adult neurons; SOX11 - 91% open in P0 to 75% open in adult neurons). (B) Promoters of JUN and STAT3 targets are largely inaccessible in adult neurons (JUN- 95% open in P0 to 45% open in adult neurons; STAT3- 93% open in P0 to 40% open in adult neurons). (C) Percent promoter accessibility of TF target genes plotted against axon growth index at 1mm from injury shows strong correlation between target gene accessibility and in vivo efficacy of pro-regenerative TFs. Red dotted line displays best line of fit (degrees of freedom – 2; R square = 0.965).