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. 2018 Oct 22;6:499. doi: 10.3389/fchem.2018.00499

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Copyright © 2018 Li, Sun, Li, Kawazoe and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The influence of hydrogel self-healing and degradation on cell functions: (A) Self-healing hydrogel formed by crosslinking of benzaldehydes at both ends of difunctionalized PEG (DF-PEG) with glycol chitosan (i). The expressions of neuronal-related genes (nestin, β-tubulin, and Map2) of cells after 3 and 7 days of culture in 3D gels, *p < 0.05 (ii). Reproduced with the permission from Tseng et al. (2015), Copyright © 2013, John Wiley and Sons. (B) (i) Schematic of sequential crosslinking of MeMaHA using a primary addition and secondary radical polymerization to create -UV and D0 UV hydrogels. (ii) Percentage of hMSCs toward osteogenic or adipogenic differentiation in -UV or D0 UV hydrogels (#p < 0:005, t-test). Reproduced with the permission from Khetan et al. (2013), Copyright © 2013, Springer Nature.