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. 2018 Oct 22;6:499. doi: 10.3389/fchem.2018.00499

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Copyright © 2018 Li, Sun, Li, Kawazoe and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of RGD peptides and growth factors in hydrogels on cell functions: (A) Schematic representation of the activation of caged RGD peptides in PEGDA hydrogels under light exposure (i). Cell adhesion and spreading can be enhanced after culture in hydrogels with RGD peptides and UV-light-exposed caged RGD peptides (ii). Reproduced with the permission from Lee et al. (2015), Copyright © 2015, Springer Nature. (B) ECM production of chondrocytes is enhanced after culture in PEG hydrogels with covalently tethered TGF-β. DNA content of chondrocytes exposed to 50 nM tethered TGF-β is the highest (i). Chondrogenic matrix (collagen and glycosaminoglycan) deposition is enhanced when exposing to TGF-β. The matrix produced in 50 nM (tethered) group is higher than that in 0.3 nM (soluble) group (ii). Reproduced with the permission from Sridhar et al. (2014), Copyright © 2014, John Wiley and Sons.