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. 2018 Oct 22;9:2307. doi: 10.3389/fimmu.2018.02307

Figure 4.

Figure 4

Impact of BI119 on T-cell-transfer colitic mice. (A) Body weight loss and colon tissue inflammation were reduced with BI119 treatment. (B) Fecal and systemic biomarkers were inhibited in BI119-treated colitic mice. Lipocalin was measured by ELISA on fecal supernatants. sCD14 was measured by ELISA on plasma samples. (C) Mucosal thickness was reduced in BI-treated colitic mice while (D) the histopathological score of colonic samples showed a trend but was not significantly decreased in BI119-treated colitic mice. (E) Hematoxylin and eosin stained histologic sections of the distal colon of different mice groups. Mean ± SEM. ns > 0.05, *P ≤ 0.05, ***P < 0.0005, ****P < 0.0001 compared to CD45+RBhigh mice.