Table 1.
Demographics of 181 families with familial and sporadic SRNS.
| Characteristic | Autosomal dominant | Autosomal recessive | Sporadic | Full cohort |
|---|---|---|---|---|
| Age at onset (median in years) [interquartile range] | 23 [15] | 20 [19] | 6 [10] | 12 [19.5] |
| SEX | ||||
| Male (%) | 22 (33.8) | 15 (71.4) | 55 (57.9) | 92 (50.8) |
| Female (%) | 43 (66.2) | 6 (28.6) | 40 (42.1) | 89 (49.2) |
| RACE | ||||
| White, Non-hispanic | 41 | 17 | 48 | 106 (58.6) |
| Black | 17 | 3 | 26 | 46 (25.4) |
| Hispanic | 6 | 0 | 14 | 20 (11.0) |
| Other | 1 | 1 | 7 | 9 (5.0) |
| HISTOLOGY | ||||
| FSGS | 39 | 14 | 56 | 109 (60.2) |
| MCD | 4 | 1 | 21 | 26 (14.4) |
| Other | 1 | 1 | 16 | 18 (10.0) |
| No biopsy (includes ESKD) | 21 | 5 | 2 | 28 (15.5) |
| US sample (%) | 48 (73.8) | 15 (71.4) | 87 (91.6) | 150 (82.9) |
Age at onset and race are defined by the proband in each family.